MUC5AC and Keratoconjunctivitis sicca: To evaluate the potential function of human corneal epithelial organoids in drug testing, we treated the human corneal organoids with three different drug: (1) Diquafosol ophthalmic solution (Diquas) is a P2Y2 receptor agonist that promotes tear and mucin secretion in dry eye patients22; Diquas treatment inhibits apoptosis and inflammation in the corneal epithelium in an animal model of DED.23