Consistent with previous studies, we found that an increased TG level driven by the APOC3(OR = 1.0086, 95%CI: 1.0037–1.0135) and LPL (OR = 1.0040, 95%CI: 1.0001–1.0078) target were associated with an increased risk of asthma. Here, APOC3 is linked to asthma.