APOE and asthma: Nicola et al. reported that LDL-1 levels were comparable between the asthma group and the healthy subjects’ group (56 ± 16% vs. 53 ± 11, p = NS), whereas LDL-2 was significantly lower in asthmatics compared to controls (35 ± 8% vs. 43 ± 10%, p = 0.0074) [56].Research suggests that LDLR plays a role in asthma by negatively regulating airway hyperreactivity and goblet cell hyperplasia through an apo E-LDLR pathway, which acts as a natural negative regulator of these asthma-related processes [57].