The MR analysis provided compelling evidence for a positive association of APOC3 (OR = 1.0086, 95% CI = 1.0037–1.0135) and LPL (OR = 1.0040, 95% CI = 1.0001–1.0078) with asthma risk, and a negative association of LDLR (OR = 0.9930, 95% CI = 0.9874–0.9987) with asthma risk. Here, LPL is linked to asthma.