The analysis showed that genetic variants associated with increased LDL levels, driven by the APOB, HMGCR, NPC1L1, and PCSK9 genes, were associated with an increased risk of CHD (APOB: OR = 1.243, 95%CI: 1.106, 1.397; HMGCR: OR = 1.444, 95%CI: 1.240, 1.682; NPC1L1: OR = 1.655, 95%CI: 1.201, 2.281; PCSK9: OR = 1.523, 95%CI: 1.303, 1.779). The gene discussed is PCSK9; the disease is coronary artery disorder.