The weight predictions were as follows: -1.04961 (ALB), − 0.24042 (CUBN), -0.57845 (HAO2), -0.33385 (GSTA1), 0.003948 (GATM), 0.146428 (BHMT), 1.077421 (PAH), 0.042221 (DPYS), and -1.61736 (SLC27A2) (Supplementary Table 1 and Figure S3). Here, CUBN is linked to pulmonary arterial hypertension.