The immunohistochemistry images of ALB, BHMT, CUBN, DPYS, GAMT, GSTA1, HAO2, PAH, SLC27A2 between control and LN glomerular tissues were shown in Fig. 10A. Among them, the glomerular tissues from the LN group exhibited an increased integrated option density (IOD) of CUBN, DPYS, PAH, and SLC27A2. This evidence concerns the gene BHMT and pulmonary arterial hypertension.