Gene ontology analysis revealed enrichment of similar pathways as the endotype signature (e.g., asthma, type 1 diabetes) and additional pathways linked to inflammasome signaling (NF-κB signaling, Th17 cell differentiation), suggesting the potential of MPL to target endotype-associated methylation (Fig. 2A). The gene discussed is NFKB1; the disease is type 1 diabetes mellitus.