Detectable KLK7 immunostaining was linked to pN + (p = 0.0005), V1 (p = 0.0037), and L1 (p < 0.0001) in colorectal adenocarcinoma, pN + in hepatocellular carcinoma (p = 0.0382), advanced pT stage in papillary thyroid cancer (p = 0.0132), and low grade of malignancy in a cohort of 719 squamous cell carcinomas from 11 different sites of origin (p < 0.0001). Here, KLK7 is linked to colorectal adenocarcinoma.