PCSK9 and coronary artery disorder: In the IVW estimates, using LDL-C from the GWAS of Sakaue et al., genetically proxied inhibition of HMGCR (IVW, OR [95%CI] = 0.620 [0.496–0.775], P = 2.77 × 10− 5), PCSK9 (IVW, OR [95%CI] = 0.449 [0.379–0.531], P = 8.72 × 10− 21), and NPC1L1 (IVW, OR [95%CI] = 0.456 [0.264–0.788], P = 4.91 × 10− 3) demonstrated significant causal associations with the reduced risk of CHD as expected.