NF-κB is a sequence-specific DNA-binding transcription factor that is over-activated in almost all cancers [58] and plays a central role in the initiation and progression of oxidative stress [44, 59, 60], there are multiple evidence shows that the NF-κB signaling pathway is closely connected with cell apoptosis and ferroptosis [20, 61, 62]. The gene discussed is NFKB1; the disease is cancer.