Focusing on the DLB group, after adjustment for covariates, we found positive associations between age and plasma p-tau181, NfL, GFAP, and YKL-40 levels (β = 0.247–0.521, P  ≤0.030) and between female sex and plasma GFAP levels (β = 0.259, P = 0.008). The gene discussed is NEFL; the disease is Lewy body dementia.