When IFN-γ positive T-cells, previously demonstrated to be immunoreactive, were subjected to in vitro incubation with target cells, the outcome revealed that CTLS, which were specific to peptide and induced by three MAGE-A4 multi-epitope peptides, were capable of recognizing and eliminating target cells, the long peptide we screened had a pan-tumor killing effect, which was universally applicable. Here, MAGEA4 is linked to neoplasm.