An estimate of the frequency of occurrence of amyloidosis was provided by a proteomics based study of a large cohort of 16,175 amyloidosis specimens (including hereditary amyloidosis) analysed from 2008–2018 showed AL amyloidosis with the highest frequency at 59.0%, followed by ATTR (28.4%), ALECT2 (3.2%), AA (2.9%), AH (2.3%) and the rest of the other types of amyloidosis were < 1.0% [17]. The gene discussed is TTR; the disease is AL amyloidosis.