Diagnosis of hereditary amyloidosis becomes more challenging due to various mutations per amyloid protein subtype: transthyretin (TTR; > 100 variants), apolipoprotein A1 (APOA1; > 20 variants), apolipoprotein A2 (APOA2; 4 variants), fibrinogen alpha (FGA; > 9 variants), lysozyme (LYZ; 10 variants) and gelsolin (GSN; 4 variants) [10–16]. Here, LYZ is linked to hereditary amyloidosis.