Therefore, Thus, the objectives of the present study were (i) to determine relative levels of oxidative stress and Phospho-RyR2 (Ser2808) from hearts of control and streptozotocin (STZ)-induced diabetic rats with cardiomyopathy, and (ii) to assess efficacies of Rb1 in scavenging oxidative stress and treatments. Here, RYR2 is linked to diabetes mellitus.