NPHS1 and Autoimmunity: To unravel cytotoxic CD8+ T lymphocyte (CTL)-driven autoimmunity in the kidney, we established a new murine model, based on NOH (nephrin, chicken ovalbumin [OVA], hen egg lysozyme [HEL]) mice, expressing membrane bound OVA on the surface of podocytes (Supplementary Fig. S1A, B) [14].