Patients with both non-diploid and PTEN loss tumours had higher HRs than those with only one of these aberrations, when compared to those with diploid and PTEN present tumours, in univariable time-invariant and time-dependent analyses (HR 2.98 vs. 2.13 and 3.10 vs. 1.88, respectively; Supplementary Fig. S5) and multivariable analyses of TFS (Supplementary Tables S8, S9). This evidence concerns the gene PTEN and neoplasm.