LIPE and type 2 diabetes mellitus: Lipe (lipase E, hormone-sensitive type) encodes the hormone-sensitive lipase (HSL), a key enzyme that is involved in the hydrolysis of intracellular triglycerides and lipolysis, releasing fatty acids as an energy substrate in adipose tissues40,41; Dysregulation of HSL expression and activity has been observed in disorders, such as obesity and T2DM, indicating its significance in adipocyte function and regulation of systemic lipid and glucose homeostais42.