Lipe (lipase E, hormone-sensitive type) encodes the hormone-sensitive lipase (HSL), a key enzyme that is involved in the hydrolysis of intracellular triglycerides and lipolysis, releasing fatty acids as an energy substrate in adipose tissues40,41; Dysregulation of HSL expression and activity has been observed in disorders, such as obesity and T2DM, indicating its significance in adipocyte function and regulation of systemic lipid and glucose homeostais42. This evidence concerns the gene LIPE and obesity due to melanocortin 4 receptor deficiency.