It plays a key role in modulating the plasminogen/plasminase system and has been associated with various conditions, including cardiovascular diseases, inflammation, cancer, metabolic disorders, aging, tissue fibrosis, etc. Plasminogen activator inhibitor (PAI)-1, a member of the Serpine1 superfamily, regulates the fibrinolytic process, and its levels are elevated in diabetes and insulin-resistant states56. The gene discussed is SERPINE1; the disease is diabetes mellitus.