MAPK1 and familial dilated cardiomyopathy: The BP annotation revealed enrichment in lipid metabolism, cell adhesion/migration, positive regulation of ERK1 and ERK2 cascade, fatty acid metabolic process, etc. Previous studies have reported that diabetic dyslipidemia and intramyocardial lipid accumulation are the key pathological features of DCM, triggering cellular signaling and modifications of proteins and lipids through toxic metabolic intermediates23,24.