For example, several clinical subgroups have been described in RA based on the presence of specific autoantibodies and/or specific immune responses; where for instance, the myeloid RA phenotype is driven by TNF, contrary to lymphoid RA type that is IL-17/IL-1-mediated, and these RA phenotypes correlate with response to treatments74. The gene discussed is TNF; the disease is rheumatoid arthritis.