The canonical osteoporosis drugs take effect mainly by promoting bone formation or inhibiting bone resorption.61 However, parathyroid hormone (PTH), a clinically utilized effective drug for osteoporosis,62 exhibited unique characteristics that promote both bone formation and bone resorption as well as regulating BMATs,13,63–65 which resembles the function of PCLAF-Nab in our study. The gene discussed is PTH; the disease is osteoporosis.