The major tissue for iron storage in mammals is liver, in which hepatocytes accumulate iron within ferritin; Li et al. [41] established a hepatocyte-targeted NCOA4 knockdown murine model in which they induced acute iron deficiency and stress erythropoiesis with phlebotomy, and they demonstrated a markedly impaired ability to degrade ferritin or mobilize iron in hepatocytes of NCOA4−/− mice, which revealed that during acute iron deficiency, NCOA4-mediated turnover of ferritin plays a role in iron mobilization from the liver. This evidence concerns the gene NCOA4 and Iron deficiency anemia.