As repletion time is prolonged, tax1-binding protein 1 (TAX1BP1) acts as a receptor for aggrephagy, binding to NCOA4 via its aa 446–484 region, then delivering ferritin to lysosomes in an autophagy-related protein (ATG) 7-independent fashion, thereby preventing iron deficiency caused by excessive iron storage [29]. The gene discussed is TAX1BP1; the disease is Iron deficiency anemia.