FBXO11 and acute myeloid leukemia: To identify AML-biased CRL dependencies, the screened CRL genes were ranked according to the difference in ES values between AML cell lines and non-AML cell lines (Fig. 1c, Supplementary Fig. 1a–c, and Supplementary Data 1), and FBXO11 and DCAF15 were revealed as top AML-dependency genes.