In line with the observation that protein levels of cleaved caspase-3 were elevated in DCAF15-knockout cells (Fig. 2d), apoptosis, measured by Annexin-V staining, was significantly up-regulated upon DCAF15 loss in TP53-WT AML cells; however, concomitant TP53-ablation rescued the observed apoptotic phenotype (Fig. 2g). The gene discussed is DCAF15; the disease is acute myeloid leukemia.