Indeed, RNA-seq demonstrated that only 5 and 1 protein-coding mRNAs were significantly down-regulated or up-regulated, respectively, in TP53/DCAF15 double-knockout (DKO) AML cells (Fig. 2e, Supplementary Fig. 2d, e, and Supplementary Data 2). This evidence concerns the gene TP53 and acute myeloid leukemia.