It was found that it downregulated the expression of CD206 (M2 macrophage marker) by 42.3%, and upregulated the proportion of CD86 (M1 macrophage marker) by 59.6%, indicating that HABP nanoparticles have the function of reshaping the tumor associated macrophage (TAM) phenotype (from pre tumor M2 TAM to anti-tumor M1 TAM). The gene discussed is CD86; the disease is neoplasm.