Both alpha-synuclein and LRRK2 are frequently implicated in neurological symptoms observed in familial and sporadic PD, with post-translational modifications (PTMs) affecting these proteins commonly detected in Lewy bodies, a pathological hallmark of PD (Singh et al. 2013; Rehni and Singh 2013; Simpson et al. 2020). The gene discussed is SNCA; the disease is Parkinson disease.