SNCA and Parkinson disease: Aberrations in alpha-synuclein have been linked to age-dependent neurological impairments, affecting synaptic integrity, neurotransmitter release, and vesicle recycling, contributing to neurodegeneration in PD as illustrated in Fig. 1 (Kalia et al. 2013; Limanaqi et al. 2018; Morris et al. 2019).