In the context of Parkinsons disease (PD), the mutated PTEN-induced putative kinase 1 (PINK1) gene is implicated in disrupting the ubiquitin–proteasome system, resulting in the impaired accumulation of proteins and contributing to dopaminergic neurodegeneration in PD (Wilkinson et al. 2010; Bonifatie 2014). The gene discussed is PINK1; the disease is Parkinson disease.