SNCA and neuroblastoma: Experimental studies using PC12 cells and SH-SY5Y human neuroblastoma cells, along with electron microscopy, have provided insights into SIAH-mediated ubiquitination enhancing alpha-synuclein aggregation and the development of alpha-synuclein-positive inclusions (Muntané et al. 2012; Chorfa et al. 2013; Muntané et al. 2012; Nascimento et al. 2020).