Generally, the high SI on precontrast T1w can be influenced by increased paramagnetic effects from prior hemorrhage (ferritin, hemosiderin, deoxyhemoglobin, and/or methemoglobin deposition) or free radicals and other nonparamagnetic effects, for example, very high (nonparamagnetic) protein concentration [32]. The gene discussed is HBG2; the disease is hemorrhage.