Interestingly, in cSBD-CLC cases, ELTD1-positive MVD at the invasive margin (CLC-rich area) was significantly higher than that at the tumor center (SBD-rich area) (Fig. 4b), indicating that the CLC component, which is located at the invasive area and shows replacing HGP, primarily utilizes vessel co-option for blood supply [11]. The gene discussed is ADGRL4; the disease is neoplasm.