Using the univariate Cox (Fig. 2A) and LASSO analysis (Fig. 2B, C), six survival-related genes (MRPS23, MPV17, MAPK3, IGF2BP2, CDK5, and IDH2) were determined as optimal OXPHOS-relevant genes for HCC prognosis. The gene discussed is IDH2; the disease is hepatocellular carcinoma.