As illustrated in Fig. 8A, IDH2 was downregulated, and MRPS23, MPV17, CDK5, MAPK3, and IGF2BP2 presented elevated expression in HCC tissues in the TCGA-HCC cohort, otherwise, the same findings were appeared in GSE50579 except for IDH2 (Fig. 8B). Here, MAPK3 is linked to hepatocellular carcinoma.