GABPB1 associates with the alpha subunit to form a tetrameric configuration that actively enhances the transcription of a myriad of genes, including those involved in antioxidant defense mechanisms, such as Peroxiredoxin 5 (PRDX5), which is highly expressed in HCC tissues and associates with poor prognosis of patients [137, 138]. Here, PRDX5 is linked to hepatocellular carcinoma.