TRPC5 and Anxiety: To test this, we used benzothiadiazine derivative (BTD), a Trpc5 activator with >15-fold selectivity for Trpc5 over other Trp channels.28 BTD significantly ameliorated anxiety-like behavior and improved social behavior in male WT mice and improved maternal behavior in female WT dams (Figure S3), providing additional evidence that these phenotypes are mediated by TRPC5.