To investigate whether rare variants in TRPC5 may be identified in other people with severe obesity, we reviewed exome sequencing data from 984 people with severe childhood-onset obesity recruited to the Genetics of Obesity Study (GOOS; www.goos.org.uk).25,26 We did not find any microdeletions overlapping TRPC5. The gene discussed is TRPC5; the disease is obesity due to melanocortin 4 receptor deficiency.