HCRT and Cataplexy: Previous studies in mice have shown that TRPC5 currents maintain orexin neurons in a depolarized state.54 Additionally, emotional cues lead to the activation of inhibitory GABAergic neurons in the central nucleus of the amygdala and induce cataplexy in orexin knockout mice.55 Understanding how TRPC5 regulates orexinergic circuits may reveal mechanisms modulating emotion/fear and states of heightened arousal.