Supplementation of OXT in male and female OXT-Trpc5-KO mice reduced food intake and body weight to levels comparable to WT mice (Figures 5G, S5J, and S5K), suggesting that OXT analogs/receptor agonists could be effective in treating human obesity due to TRPC5 deficiency. Here, OXT is linked to obesity due to melanocortin 4 receptor deficiency.