We found high levels of Trpc5 expression in oxytocin (OXT) neurons in the paraventricular nucleus of the hypothalamus (PVH) known to regulate energy homeostasis and the response to stress, emotion, and social behaviors, including mother-infant bonding.21–23 Deletion of Trpc5 from PVH OXT neurons caused severe hyperphagic obesity, postpartum depressive behavior, and reduced maternal care, while Trpc5 overexpression in PVH OXT neurons in knockin mice reversed these phenotypes. The gene discussed is TRPC5; the disease is obesity due to melanocortin 4 receptor deficiency.