TRPC5 and obesity due to melanocortin 4 receptor deficiency: Experiments in TSE PhenoMaster metabolic cages confirmed increased food intake and decreased locomotor activity but no change in energy expenditure (using body mass as a covariate), indicating that hyperphagia is the major driver of obesity in mice lacking Trpc5 in OXT neurons (Figures 5E, 5F, S5H, and S5I).