Previous studies have shown that Trpc5 depolarizes Pomc neurons, and targeted deletion of Trpc5 from these neurons leads to hyperphagia and obesity.20 Here, we found that administration of BTD reduced both chow and HFD intake in WT mice (Figures 4B and 4C), without causing aversive effects measured using the kaolin intake test and the conditioned flavor avoidance test (Figures S4A–S4D). Here, TRPC5 is linked to obesity due to melanocortin 4 receptor deficiency.