Only four gene products were increased in both expression and abundance in T2D: RNA-binding protein with multiple splicing (RBPMS), AP-3 complex subunit sigma-1 (AP3S1), which is involved in lysosomal trafficking,22 syntaxin binding protein 6 (STXBP6), which is thought to limit insulin release by limiting the size of the granule fusion pore,23 and beta arrestin 1(ARRB1), which is suggested to be involved in glucagon-like peptide-1 (GLP-1) stimulated insulin secretion.24 The gene discussed is AP3S1; the disease is type 2 diabetes mellitus.