For example, while both first and second phase insulin secretion in response to high glucose were blunted in islets from donors with T2D, we did not detect significantly impaired amino acid-stimulated insulin secretion, which bolsters the case that protein-rich diets could have therapeutic benefits in patients with T2D 57 and highlights the need for additional research into amino-acid stimulated insulin secretion. This evidence concerns the gene INS and type 2 diabetes mellitus.