KRT7 and cancer: At the individual gene level, we found 23 genes up-regulated in infected tumor cells in both cancer types (13-fold over-enrichment; P < 1 × 10−19), including the cytoskeletal gene KRT7, which is up-regulated by F. nucleatum infection and promotes metastasis of colorectal carcinoma (47), and 12 genes involved in antigen processing and presentation of peptides on human leukocyte antigen (HLA) class I and class II (see fig.