Both Barrett et al. (48) and Tian et al. (49) used a fractionation methodology to enrich for matrix proteins from the tumors of pancreatic cancer GEMMs, namely, the KTC (Ptf1a-Cre; LSL-KrasG12D/+; Tgfbr2fl/+) mouse model (48) or KC (Pdx1-Cre; LSL-K-rasG12D/+) and KPC pancreatic mouse models (49). This evidence concerns the gene CALCA and familial pancreatic carcinoma.