In cancer, high NID2 expression has previously been associated with several solid malignancies including gastric cancer (40), esophageal squamous cell carcinoma (41), ovarian cancer (42), melanoma (43), and breast cancer (44, 45), although its causal role in pancreatic cancer and fibrosis progression remains unexplored. Here, NID2 is linked to esophageal squamous cell carcinoma.