The KPflC mouse model, in which pancreatic cancer cells have lost p53 expression, is characterized by poor metastatic spread (37) and lower levels of fibrosis (28) compared to the highly metastatic KPC mouse model, which expresses a gain-of-function p53 R172H mutation (mouse analog; equivalent to human R175H), commonly found in patient pancreatic tumors. Here, TP53 is linked to familial pancreatic carcinoma.