SLC7A11 and malignant colon neoplasm: Indeed, in both breast and colon cancer cells, KCTD10 knockdown caused the accumulation of endogenous SLC7A11 (Fig. 2F and SI Appendix, Fig. S2D), whereas KCTD10 overexpression reduced the levels of endogenous SLC7A11 in a dose-dependent manner (Fig. 2G and SI Appendix, Fig. S2E).