USP18 and neoplasm: Consistently, the IHC-staining of a breast tumor tissue microarray, containing large number of tumor tissues (n = 142) and the adjacent normal tissues (n = 58) showed that compared to adjacent normal tissues, tumor tissues had significantly higher levels of SLC7A11 and USP18, but low levels of KCTD10 (Fig. 7 B–D and SI Appendix, Fig. S8H).