This panel included the four genes overexpressed in the three conditions (CCNA2, CDCA5, FOXM1, and UBE2C); EGLN3, the most overexpressed gene in high-grade MTC; SOX2, a cancer stem cells related transcription factor overexpressed in high-grade follicular-derived thyroid carcinomas [17]; the two genes overexpressed exclusively in a high-grade subset (CENPA and DLL3); and ASCL1, not included in the NanoString Tumor Signaling 360 Panel. The gene discussed is EGLN3; the disease is thyroid gland carcinoma.