DLL3 and medullary thyroid gland carcinoma: Two genes were upregulated in high-grade MTC that did not appear in the subsets of proliferation or necrosis: CENPA and DLL3. CENPA encodes for a histone H3-like nucleosomal protein found in centromeric nucleosomes, which is also required for the assembly of kinetochore proteins, so it is implicated in cell cycle progression [37, 38].