FOXM1 and cancer: The four genes that were overexpressed in the three morphological conditions (high grade, high proliferation, and the presence of necrosis) are genes required for cell cycle progression: Cyclin A2 (CCNA2), Cell Division Cycle Associated 5 (CDCA5), Forkhead Box M1 (FOXM1), and Ubiquitin Conjugating Enzyme 2C (UBE2C). The upregulation of these genes is expected in conditions with increased proliferation, and they are commonly identified as worse prognostic parameters in many cancer datasets [29, 30].