MAPT and Alzheimer disease: In earlier studies, it has been reported that apoE−/− mice have a higher risk for developing AD-related symptoms such as memory defects, tau protein hyperphosphorylation, leaky blood–brain barrier, and even Aβ deposits in the brain when compared with wild-type control animals (Lane-Donovan et al. 2016; Saul and Wirths 2017; Saroja et al. 2022).