BCL6 and systemic lupus erythematosus: Ding Shu et al. tested the role of BCL-6 transcription repressor (BCL-6) on miR-142 downregulation seen in SLE, and their results showed that activated BCL-6 directly binds to a promoter-proximal element of mir-142 in healthy cells and in SLE T4 cells this binding is stronger [61].