This complex comprises the RNase III enzymes Drosha ribonuclease III (DROSHA) and DiGeorge syndrome chromosomal region (DGCR), which work together to cut every hairpin structure from long pri-miRNA to produce single hairpins called pre-miRNAs which are ~ 55 to 70 nucleotides long. Here, DROSHA is linked to 22q11.2 deletion syndrome.