TP53 and systemic lupus erythematosus: Abnormally active B cells are seen in SLE patients with decreased p53 expression and dysregulated miRNA profile, and Zhang et al. studied the mechanism of tumor protein 53 (p53) and mir-1246 interactions in B cells and found an increase in H3K27me3 and a decrease in H3K9/K14ac in the miR-1246 promoter site [60].