Wnt5A signalling was found to directly augment motility of human melanoma cells, with further investigations characterising a putative Wnt5a-ROR2-Calpain axis (ROR2 is an orphan tyrosine kinase receptor previously shown to interact with Wnt5a) culminating in filamin cleavage, cytoskeletal remodelling and increased metastatic potential [67]. This evidence concerns the gene ROR2 and melanoma.