Conclusive experimentation using the FLNa-deficient M2 human melanoma cell line showed that impaired migration of M2 cells could be rescued by transfection of WT filamin A but blocked again by treatment with the MEK inhibitor UO126 suggesting that MAPK controlled filamin A phosphorylation is essential in growth factor stimulated-cell migration [45,49]. The gene discussed is FLNA; the disease is melanoma.