APP and Alzheimer disease: For example, the functional role of Npas4 in neuronal health and AD pathology will be investigated in animal models through gene manipulation (such as knockdown or overexpression studies) to explore the effects of Npas4 regulation on cognitive function and synaptic integrity in APP/PS1 mice, develop small molecule or gene manipulation to modulate Npas4 and test its efficacy in preclinical AD models, and to explore the combination therapy of Aβ deposition and Npas4 pathway to improve the therapeutic effect.