Arbutin inhibits osteosarcoma cell proliferation, migration, and invasion via miR-338-3pl MTHFD1L (methylenetetrahydrofolate dehydrogenase (NADP+ Dependent) 1 Like) and by inactivating the AKT (protein kinase B)/mTOR (mammalian target of rapamycin) signaling pathway (8). This evidence concerns the gene AKT1 and osteosarcoma.