TNFSF14 and cancer: LIGHT, also known as TNFSF14, is a homotrimerictype II transmembraneprotein expressed on activated T-cells and immature dendritic cells.2,4 It is involved in various biological processes, including inflammation,immune regulation, and apoptosis, and plays a critical role in thepathogenesis of various autoimmune diseases and cancer,10 as well as COVID-19-induced pneumonia and inflammation.11 Therefore, understanding the molecular mechanismsof LIGHT signaling is crucial for developing new therapies for thesediseases.