The enrichment of numerous glycoside hydrolases, including ten involved in mucin degradation, in the microbiome of mice with DSS colitis is likely a reflection of the ability of these species to inhabit intestinal mucus and where complex glycans are an abundant energy source.16 Although the mechanism by which glycan degrading bacteria are enriched in DSS colitis remains to be determined, the ability to reproduce the same induction of both Bacteroides spp. Here, MUC5AC is linked to colitis.