SCN5A and Brugada syndrome: For example, genetic variants in the SCN5A gene of individuals with LQTS are more prevalent in African American people, increasing the risk of sudden death (Killen et al., 2010), while Brugada syndrome (BrS) associated with SCN5A variants have been reported more frequently in Caucasians and Asians individuals (Milman et al., 2019; Chen et al., 2020; Nakano and Shimizu, 2022), although BrS phenotype is more prevalent in East and Southeast Asia (Nakano and Shimizu, 2022; Khawaja et al., 2023).