TGFB1 and allergic disease: Insufficient differentiation and functional defects of Tregs are key factors in the enhancement of Th2 responses and the occurrence of allergies, which are mainly manifested in the fact that TGF-β and IL-10 secreted by Tregs can significantly inhibit airway inflammation and hyperresponsiveness while blocking TGF-β or IL-10 aggravates airway inflammation and hyperresponsiveness (195).