It also has an affinity for heparin and heparan sulphate.32 Furthermore, the human ligands for selectin E include those that contain sLex and the glycosphingolipid VIM2 epitope.26 Taken together, the structural differences observed among the naturally-occurring ligands for human selectins support the concept that while those containing sLex synthesised by FUT7 are important, they are not the only counter receptors that can function in selectin-mediated cell adhesion, such as occurs during blood vessel occlusion in SCD. This evidence concerns the gene SELE and Schnyder corneal dystrophy.