FN1 and corneal infection: Furthermore, S. pneumoniae shows enormous plasticity in its ability to interact with FN as it expresses several FN-binding proteins on its surface, including PavA, PavB, endopeptidase O, RrgA, PfbA, and PfbB.17,70,71 Although PavA is thought to be the dominant FN-binding protein that mediates S. pneumoniae binding to FN fibrils during corneal infection,12 the role of other FN-binding proteins in corneal pathogenesis has not been tested.