LGALS9 and rheumatoid arthritis: The result showed that Gal-9 >11.6 ng/mL (OR=3.138, 95% CI 1.150–8.567, p=0.026), HAQ >1 (OR=3.991, 95%CI 1.578–10.090, p=0.003) and Pain VAS >4 (OR=7.536, 95%CI 2.837–20.017, p <0.001) were independent risk factors for high disease activity in patients with RA (Figure 6; Supplementary Table S1).