Plasma exosomes were significantly higher in patients with COPD exacerbations and stable COPD patients compared to healthy controlsExosomes were numerically higher in patients with COPD exacerbations compared to stable COPD patientsCirculating exosomes level correlated with CRP, sTNFR1, and IL-6 levels. The gene discussed is CRP; the disease is chronic obstructive pulmonary disease.