IL6 and acne: Cutibacterium acnes stimulates cytokine secretion, such as interleukin (IL)-6 and IL-8, which eventually causes inflammation.5 According to the guideline of care for acne vulgaris,6 topical benzoyl peroxide (BPO) or topical retinoids and the topical combination of BPO and retinoids are the first line of treatment in mild and moderate acne vulgaris, respectively.