CXCL8 and acne: Vitamin D can inhibit C. acnes-induced Th17 differentiation,16 lower the production of IL-6, IL-8, and metalloproteinase 9 in cultured sebocytes17 and promote antimicrobial peptides.18 Vitamin D also affects the proliferation and development of sebocytes and keratinocytes.19 Previous meta-analysis research12 demonstrated that low levels of vitamin D may be linked to acne development and potentially related to its severity.