Brown et al. demonstrated that induced TAMs can express FasL and release active soluble FasL in order to induce apoptosis of the Fas+lymphocyte (Brown and Savill, 1999), while CAFs (cancer associated fibroblasts) can upregulate FasL and PD-L2 via the cross-presentation of MHC-1 (major histocompatibility complex1) antigen and inhibit CD8+ T cells activity, thus elicit an immunosuppressive TME (De Jaeghere et al., 2019). Here, PDCD1LG2 is linked to cancer.