Fever, jaundice, nausea and fatigue, AIHA (Hb 6.0 g/dL, serum bilirubin 2.3 mg/dL serum unconjugated bilirubin 0.84 mg/dL, LDH 537 UI/l, serum haptoglobin <5 mg/dL). DAT was positive. The gene discussed is HP; the disease is Fever.