BRCA2 and ovarian carcinoma: reported that the free energy of binding (ΔG) of berberine to ovarian cancer cell lines was -7.5 kcal/mol, and the free energy of binding of berberine to PALB/BRCA2 was -8.8 kcal/mol, which demonstrated that the effective and tight binding of the complexes enhances the radiosensitivity of ovarian cancer cell lines and is a promising nutritional candidate for anticancer diagnosis (70).