CGAS and neoplasm: By triggering the release of PPI and Mn2+ and activating immune cell recruitment in the tumor microenvironment, the system remodels the tumor microenvironment, enhances the antitumor immune response mechanism mediated by the cGAS/STING pathway, and transforms malignant tumors from cold to hot, thus perfecting the mechanisms and therapeutic strategies related to antitumor immunotherapy (64).