SHBG and diabetes mellitus: Altered SHBG levels have been associated with polycystic ovarian syndrome, Cushing's syndrome, hypothyroidism, acromegaly, obesity, use of anabolic steroids, hyperthyroidism, oral contraceptives, anorexia nervosa, cirrhosis and Type 2 Diabetes Mellitus (T2DM).3–6 Crucial to this study is its relationship with T2DM, where a reduction in its serum levels increases the probability of the disease.3