SHBG and type 2 diabetes mellitus: This SHBG reduction, alongside certain genetic polymorphisms, leads to and is strongly associated with insulin resistance and, consequently, T2DM.3,7 Pregnancy-induced impairment of glucose tolerance as a result of pancreatic beta cell dysfunction on a background of increasing insulin resistance has been identified as the pathologic hallmark of gestational diabetes mellitus (GDM),8 hence the association between GDM and SHBG.