This SHBG reduction, alongside certain genetic polymorphisms, leads to and is strongly associated with insulin resistance and, consequently, T2DM.3,7 Pregnancy-induced impairment of glucose tolerance as a result of pancreatic beta cell dysfunction on a background of increasing insulin resistance has been identified as the pathologic hallmark of gestational diabetes mellitus (GDM),8 hence the association between GDM and SHBG. This evidence concerns the gene SHBG and gestational diabetes.