When adjusted for all possible confounders including maternal age, parity, history of first-degree relations with DM, previous multiple pregnancies, and previous macrosomia, the serum level of SHBG at 24 – 28 weeks gestation in the study participants was significantly negatively correlated with the presence of GDM (rpb = −0.534, p = 0.001) diagnosed via 75g OGTT. This evidence concerns the gene SHBG and diabetes mellitus.