The World Health Organization (WHO) defines infertility as “the incapability of a couple to conceive in spite of having regular sexual activity for at least one year without using any contraceptive methods”.1 Around the world, approximately 15% of reproductive-age couples are struggling with infertility,2 about half of these issues are related to male factors.3 There are many causes contributing to male infertility, including infection,4 alteration in organ function,5 environmental factors, genetic factors,6 and sex hormone disturbance.7 The gene discussed is PLXNA3; the disease is Infertility.