KDR and Myocardial fibrosis: Rg1, a potent proangiogenic agent, induced the angiogenesis by targeting RUNX2 and increasing the vascular endothelial growth factor receptor-2 (VEGFR-2) in ischemic injury [102, 103], which reduced the myocardial fibrosis and left ventricular hypertrophy by increasing the expression of HIF-1 and VEGF [104].