PPARGC1A and type 2 diabetes mellitus: Deng et al. reported that PDS and PTS treated the high-fat diet/streptozocin-induced type 2 diabetes mellitus (T2DM) mice by inhibiting expression of hepatic metabolism genes (peroxisome proliferator-activated receptor gamma coactivator 1-alpha, phosphoenolpyruvate carboxykinase, and glucose-6-phosphatase) and promoting the expression of lipid metabolism genes (microsomal triglyceride transfer protein).